Spindle-cell Tumours of the Larynx: Diagnostic Pitfalls. A Case Report and Review of the Literature

Gino Marioni Department of Otolaryngology--Head and Neck Surgery Institute of Pathological Anatomy Padua

Raffaele Bottin Department of Otolaryngology--Head and Neck Surgery Institute of Pathological Anatomy Padua

Alberto Staffieri Department of Otolaryngology--Head and Neck Surgery Institute of Pathological Anatomy Padua

Giuseppe Altavilla Institute of Pathological Anatomy, University of Padua Padua

Abstract

Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possible after immunohistochemical investigations of the expression of specific tumour markers but electron microscopic observations help to clarify most of these diagnoses.

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Spindle-cell Tumours of the Larynx: Diagnostic Pitfalls. A Case Report and Review of the Literature

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