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Scandinavian Journal of Infectious Diseases Volume 35, 2003 - Issue 11-12
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Original Paper

Atovaquone/proguanil Resistance in Africa: a Case Report

Kim P. David Department of Infectious Diseases, Rigshospitalet, CopenhagenCorrespondence(E-mail. [email protected])
,
Michael Alifrangis Department of International Health, Institute of Public Health, University of Copenhagen
,
Ali Salanti Department of Infectious Diseases, Rigshospitalet, Copenhagen
,
Lasse S. Vestergaard Department of International Health, Institute of Public Health, University of Copenhagen
,
Anita Rønn Department of Infectious Diseases, Rigshospitalet, Copenhagen
&
Ib Bygbjerg Department of International Health, Institute of Public Health, University of Copenhagen
Pages 898-899 | Received 15 Aug 2003, Accepted 26 Aug 2003, Published online: 08 Jul 2009
 
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Abstract

The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.

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