Impact of Prolonged Treatment with Trimethoprim-sulfamethoxazole on the Human Gut Flora

Diamantis P. Kofteridis Department of Internal Medicine, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece

Sofia Maraki Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece

Ioanna Mixaki Department of Internal Medicine, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece

Elpis Mantadakis Department of Internal Medicine, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece

George Samonis Department of Internal Medicine, Infectious Diseases Unit, University Hospital of Heraklion, Heraklion, Crete, Greece

Abstract

The case of a mentally ill man inadvertently treated with trimethoprim-sulfamethoxazole (TMP-SMX) for 2 y is presented. Quantitative stool cultures revealed a substantially suppressed Gram-negative aerobic flora, while Enterococcus spp. and anaerobes were not affected. Yeasts were moderately increased. TMP-SMX represents an attractive antimicrobial for immunocompromized patients who need the integrity of their intestinal anaerobic flora for colonization resistance.

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Impact of Prolonged Treatment with Trimethoprim-sulfamethoxazole on the Human Gut Flora

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Impact of Prolonged Treatment with Trimethoprim-sulfamethoxazole on the Human Gut Flora

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