Successful Treatment of Pulmonary Mucormycosis in an Allogenic Bone-marrow Transplant Recipient with Combined Medical and Surgical Therapy

Juliette Pavie Service des Maladies Infectieuses et Tropicales, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Matthieu Lafaurie Service des Maladies Infectieuses et Tropicales, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Claire Lacroix Laboratoire de Mycologie et Parasitologie, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Anne Marie Zagdanski Service de Radiologie, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Denis Debrosse Service de Chirurgie Thoracique, Institut Mutualiste Montsouris, Paris, France

Gérard Socié Service de Greffe de Moëlle, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Francis Derouin Laboratoire de Mycologie et Parasitologie, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Eliane Gluckman Service de Greffe de Moëlle, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

Jean Michel Molina Service des Maladies Infectieuses et Tropicales, Hôpital Saint Louis, Assistance, Publique-Hôpitaux de Paris, Paris, France

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Abstract

Mucormycosis is a rare, but severe, complication in allogenic bone-marrow recipients with a mortality rate of about 80%. Moreover, its incidence appears to have increased within the last decade. We report a case of pulmonary and nasal mucormycosis in a 55-y-old patient, which occurred 1 y after BMT. Treatment combining 4 months of amphotericin B, early surgical resection of infected tissue and discontinuation of immunosuppressive treatment allowed the cure of this mould infection.

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Successful Treatment of Pulmonary Mucormycosis in an Allogenic Bone-marrow Transplant Recipient with Combined Medical and Surgical Therapy

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Successful Treatment of Pulmonary Mucormycosis in an Allogenic Bone-marrow Transplant Recipient with Combined Medical and Surgical Therapy

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