A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56^bright NKcells

Tomohiro Kubo From the Department of Pediatrics, National Defense Medical College, Saitama, JapanCorrespondence[email protected]

Kengo Sato From the Department of Pediatrics, National Defense Medical College, Saitama, Japan

Daisuke Kobayashi From the Department of Pediatrics, National Defense Medical College, Saitama, Japan

Akira Motegi From the Department of Pediatrics, National Defense Medical College, Saitama, Japan

Osamu Kobayashi From the Department of Pediatrics, National Defense Medical College, Saitama, Japan

Seiichirou Takeshita Department of School Health Science, Faculty of Education, Ibaraki University, Ibaraki, Japan

Shigeaki Nonoyama From the Department of Pediatrics, National Defense Medical College, Saitama, Japan

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Abstract

We describe a 15-month-old girl with acute necrotizing encephalopathy (ANE) associated with HHV-6. Inflammatory cytokines were elevated in the CSF and serum and the number of CD56^bright NK cells was significantly increased in the peripheral blood. CD56^brightNK cells may be involved in the pathogenesis of ANE by producing inflammatory cytokines.

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A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56^bright NKcells

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A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56^bright NKcells