Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China

Kai Li From the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,; Key Laboratory of Tropical Diseases Control, Ministry of Education,

Ai He From the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,

Wei Ping Cai Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, China

Xiao Ping Tang Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, China

Xiao Ying Zheng From the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,

Zhuo Ya Li From the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,

Xi Mei Zhan From the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,; Key Laboratory of Tropical Diseases Control, Ministry of Education,Correspondence[email protected]

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Abstract

Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia. Here the P. jirovecii DHPS gene was amplified from bronchoalveolar fluid of 10 AIDS patients in China. No DHPS gene mutations were observed. The results suggest that the prevalence of DHPS mutations in China may be low.

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Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China

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Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China

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