Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient

Vega A. Goedecke From the Department of Internal Medicine, Division of Nephrology and Hypertension,

Christian Clajus From the Department of Internal Medicine, Division of Nephrology and Hypertension,

Olaf Burkhardt Department of Internal Medicine, Division of Pulmonary Medicine, Medical School Hannover, Hannover

Jens Martens-Lobenhoffer Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany

Stefanie M. Bode-Böger Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany

Jan T. Kielstein From the Department of Internal Medicine, Division of Nephrology and Hypertension,Correspondence[email protected]

Marcus Hiss From the Department of Internal Medicine, Division of Nephrology and Hypertension,

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Abstract

In this report we present pharmacokinetic (Pk) data of daptomycin given intravenously in a peritoneal dialysis patient. Daptomycin plasma levels were within therapeutic range; however, half-life of the drug was prolonged compared to haemodialysis. Both plasma and dialysate levels were found to be consistently above the minimal inhibitory concentration for daptomycin sensitive strains.

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Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient

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Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient

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