Hypercalcemia and Acute Renal Failure Caused by Production of Parathyroid Hormone-Related Protein from Renal Cell Carcinoma

Munehisa Ueno Department of Urology, Keio University School of Medicine, Tokyo, Japan

Takashi Ohigashi Department of Urology, Keio University School of Medicine, Tokyo, Japan

Jun Nakashima Department of Urology, Keio University School of Medicine, Tokyo, Japan

Shoichi Nonaka Department of Urology, Kidney Disease Center, Saitama Medical School, Saitama, Japan

Nobuhiro Deguchi Department of Urology, Kidney Disease Center, Saitama Medical School, Saitama, Japan

Masaru Murai Department of Urology, Keio University School of Medicine, Tokyo, Japan

Abstract

A 69-year-old male patient was diagnosed with right-sided renal cell carcinoma and humoral hypercalcemia of malignancy caused by an excessive production of parathyroid hormone-related protein. The hypercalcemia led to acute tubular necrosis, so the patient had to be put on hemodialysis. The renal failure was accompanied by hyponatremic encephalopathy. Rapid correction of the hyponatremia might have initiated central pontine myelinolysis.

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Hypercalcemia and Acute Renal Failure Caused by Production of Parathyroid Hormone-Related Protein from Renal Cell Carcinoma

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Hypercalcemia and Acute Renal Failure Caused by Production of Parathyroid Hormone-Related Protein from Renal Cell Carcinoma

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