An Alternative Stereoselective Synthesis of Protected Trans-5-Alkyl-4-Hydroxy-2-Pyrrolidinones

Pei Qiang Huang Department of Chemistry, Xiamen University, Fujian, Xiamen, 361005, PR CHINA

Xu Tang Department of Chemistry, Xiamen University, Fujian, Xiamen, 361005, PR CHINA

An Qi Chen Department of Chemistry, Xiamen University, Fujian, Xiamen, 361005, PR CHINA

Abstract

A flexible approach to protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones was described. The key step involved the α-amidoalkylation of benzene-sulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and anhydrous ZnCl₂-OEt₂.

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An Alternative Stereoselective Synthesis of Protected Trans-5-Alkyl-4-Hydroxy-2-Pyrrolidinones

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An Alternative Stereoselective Synthesis of Protected Trans-5-Alkyl-4-Hydroxy-2-Pyrrolidinones

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