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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 17
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Original Articles

A Rapid, Nearly Quantitative Conversion of Codeine to Hydrocodone

T. Howard Black Department of Chemistry, Eastern Illinois University, Charleston, IL, 61920
,
Jennifer C. Forsee Department of Chemistry, Eastern Illinois University, Charleston, IL, 61920
&
Donald A. Probst Department of Chemistry, Eastern Illinois University, Charleston, IL, 61920
Pages 3195-3201 | Received 26 Nov 1999, Published online: 04 Dec 2007
 
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Abstract

A very rapid, two-step, virtually quantitative synthesis of hydrocodone from codeine, via the intermediacy of dihydrocodeine, has been developed.

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