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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 22
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Original Articles

An Alternative Synthesis of 2-Chloro-5-Hydroxypyridine: A Key Component of the Non-Opioid Analgesic Agent ABT-594

Grant R. Krow Department of Chemistry, Temple University, Philadelphia, PA, 19122
,
Yushi Xiao Department of Chemistry, Temple University, Philadelphia, PA, 19122
,
Kevin Cannon Department of Chemistry, Temple University, Philadelphia, PA, 19122
,
Scot A. Swan Department of Chemistry, Temple University, Philadelphia, PA, 19122
&
Andrew Nickel Department of Chemistry, Temple University, Philadelphia, PA, 19122
Pages 4093-4096 | Received 15 Feb 2000, Published online: 04 Dec 2007
 
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Abstract

The synthesis of the biologically useful synthon 2-chloro-5-hydroxypyridine from 3-iodo-6-chloropyridine is described.

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