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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 5
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Original Articles

Superior Chiral Retention with Lithium Amide in Cyanomethylation of N,N-Dibenzyl L-Phenylalanine Benzyl Ester

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Pages 955-961 | Received 07 Jul 1999, Published online: 04 Dec 2007
 

Abstract

Lithium amide is shown to give better retention of chirality over sodium amide in the nucleophilic addition of acetonitrile to N,N-dibenzyl L-phenylalanine benzyl ester. Solvent effect is obvious in the case of sodium amide.

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