A New Palladium-Catalyzed P-C Coupling Reaction: Synthesis of Triarylphosphine Oxides and Diarylmethylphosphine Oxides

Gene A. Stark Institut für Organische Katalyseforschung (IfOK), Buchbinderstr. 5-6, 18055, Rostock, Germany

Thomas H. Riermeier Institut für Organische Katalyseforschung (IfOK), Buchbinderstr. 5-6, 18055, Rostock, Germany

Matthias Beller Institut für Organische Katalyseforschung (IfOK), Buchbinderstr. 5-6, 18055, Rostock, Germany

Abstract

The first palladium-catalyzed P-C coupling reaction of aryl halides with (hydroxymethyl)phosphines is described. Hydroxymethylphosphines act as cheap and easy to use H₃PO and CH₃P(O)H₂ equivalents. Tertiary diarylmethylphosphine oxides 5 and triarylphosphine oxides 6 are accessible in a one pot reaction in overall yields between 45-60%.

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A New Palladium-Catalyzed P-C Coupling Reaction: Synthesis of Triarylphosphine Oxides and Diarylmethylphosphine Oxides

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A New Palladium-Catalyzed P-C Coupling Reaction: Synthesis of Triarylphosphine Oxides and Diarylmethylphosphine Oxides

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