An Efficient Synthesis of ¹⁵N-Hydroxyurea

Genichiro Yasaki Department of Chemistry, Wake Forest University, Winston-Salem, NC, 27109 Fax: E-mail: [email protected]

Yueping Xu Department of Chemistry, Wake Forest University, Winston-Salem, NC, 27109 Fax: E-mail: [email protected]

S. Bruce King Department of Chemistry, Wake Forest University, Winston-Salem, NC, 27109 Fax: E-mail: [email protected]

Abstract

Treatment of trimethylsilyl isocyanate with ¹⁵N-hydroxylamine hydrochloride produces ¹⁵N-hydroxyurea, a valuable pharmacological tool, in an efficient, one-pot procedure in 74% yield. Recrystallization of the crude product yields analytically pure material in 47% overall yield.

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An Efficient Synthesis of ¹⁵N-Hydroxyurea

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An Efficient Synthesis of ¹⁵N-Hydroxyurea