An Efficient Method for N-Nitrosation of Secondary Amines Under Mild and Heterogeneous Conditions

Abstract

A combination of inorganic acidic salts or silica gel supported inorganic acids and sodium nitrite in the presence of wet SiO₂ was used as an effective nitrosating agent for the nitrosation of secondary amines to their corresponding nitroso drivatives under mild and heterogeneous conditions in moderate to excellent yields. Mg(HSO₄)₂ and NaHSO₄ are superior to all the aforementioned reagents in convenience, yield and purity of the isolated nitrosoamines.