3,4-Dihydropyrimidin-2(1H)-Ones: Fast Synthesis Under Microwave Irradiation in Solvent Free Conditions

Hélio A. Stefani Departamento de Farmácia, Faculdade de Ciěncias Farmacěuticas, Universidade de São Paulo, São Paulo, SP, Brasil E-mail: [email protected]

Paula M. Gatti Departamento de Farmácia, Faculdade de Ciěncias Farmacěuticas, Universidade de São Paulo, São Paulo, SP, Brasil E-mail: [email protected]

Abstract

Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds, in one-pot reaction between β-keto esters, aryl aldehydes, and urea. These solvent-free reactions show that it is possible to prepare these compounds in a short time reaction and with good yield and easily isolable.

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3,4-Dihydropyrimidin-2(1H)-Ones: Fast Synthesis Under Microwave Irradiation in Solvent Free Conditions

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3,4-Dihydropyrimidin-2(1H)-Ones: Fast Synthesis Under Microwave Irradiation in Solvent Free Conditions

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