Synthesis, Structure, and Biological Activity of Novel 1H‐1,2,4‐Triazol‐1‐yl‐thiazole Derivatives

Shao Ling State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, China

Zhou Xin State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, China

Zhang Qing State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, China

Liu Jian‐Bing State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, China

Jin Zhong State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, China

Fang Jian‐Xin State Key Laboratory of Elemento‐organic Chemistry, Institute of Elemento‐organic Chemistry, Nankai University, Tianjin, ChinaCorrespondence[email protected]

Abstract

2‐Amino‐4‐aryl‐5‐(1H‐1,2,4‐triazol‐1‐yl)thiazole derivatives were synthesized from the reaction of α‐bromo substituted acetophenone and thiourea. The structures were confirmed by elemental analysis, ¹H NMR and single crystal X‐ray diffraction analysis. Biological evaluation showed that some of them possess antifungal and plant growth regulatory activities.

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Acknowledgments

We gratefully acknowledge the National Natural Science Foundation of China (NNSFC) (No. 20172030) and the Key Project of Chinese Ministry of Education (No. 105046) for financial support.

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Synthesis, Structure, and Biological Activity of Novel 1H‐1,2,4‐Triazol‐1‐yl‐thiazole Derivatives

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Synthesis, Structure, and Biological Activity of Novel 1H‐1,2,4‐Triazol‐1‐yl‐thiazole Derivatives

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