Efficient and Convenient Method for the Synthesis of Symmetrical Triindolylmethanes Catalyzed by Iodine

Abstract

Indoles reacted with triethyl orthoformate in the presence of a catalytic amount of iodine at room temperature to give the corresponding symmetrical triindolylmethanes (TIMs) in good to high yields.

Keywords:

• indoles
• iodine
• triethyl orthoformate
• triindolylmethanes

Acknowledgment

We thank the Science Research Foundation of Hebei Normal University for financial support of this work.