Facile Synthesis of Triarylpyrimidines with Microwave‐Irradiated Reactions of N‐Phenacylpyridinium Chloride

Abstract

In a system of ammonium acetate and acetic acid under microwave irradiation, N‐phenacylpyridinium chloride 1 reacted with 2 mol of aromatic aldehydes 2a–h to give 2,4,6‐triarylpyrimidine 3a–h, reacted with pyridinecarboxaldehyde 4a–c and acetophenone 5 to yield bipyridine derivatives 6a–c. The structure of the products was characterized with ¹H NMR, ¹³C NMR, IR, and mass spectroscopy.

Keywords:

• aldehyde
• condensation
• microwave irradiation
• pyridine
• pyrimidine