Abstract
Simple N‐heterocycles were converted to N‐phosphono‐ and phosphinoxidomethyl derivatives by a solvent‐free microwave‐assisted condensation of the heterocycle, paraformaldehyde, and diethylphosphite or diphenylphosphine oxide in a convenient and, in most cases, efficient way. In contrast to an earlier report, imidazole proved to be unreactive in this type of phospha‐Mannich reaction.
Acknowledgment
This work was supported by the joint funds from the European Union and the Hungarian State (GVOP‐3.2.2‐2004‐07‐0006/3.0). The financial support from Gedeon Richter Ltd is also acknowledged. I. P. is grateful to the Hungarian Scientific Research Funds (OTKA PD 050010) for the support.