One‐Pot Preparation of Fluorinated α‐Aminoalkyl Phosphonates under Microwave Irradiation and Solvent‐Free Conditions

Xiao‐yong Lv Department of Chemistry, School of Science, Shanghai University, Shanghai, China

Jian‐min Zhang Department of Chemistry, School of Science, Shanghai University, Shanghai, China

Chun‐hui Xing Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China

Wei‐qiong Du Department of Chemistry, School of Science, Shanghai University, Shanghai, China

Shi‐zheng Zhu Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, ChinaCorrespondence[email protected]

Abstract

A facile one‐pot method has been developed for the synthesis of fluorine‐containing α‐amino phosphonates in good yields by a three‐component reaction of fluorinated aromatic aldehydes, anilines, and diethyl phosphate in the presence of a silica‐gel support under microwave irradiation within 10 min. All new compounds are fully characterized by spectral methods and elemental analysis.

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Acknowledgments

This work was supported by the National Science Foundation of China (Nos. 20472106, 20532040).

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One‐Pot Preparation of Fluorinated α‐Aminoalkyl Phosphonates under Microwave Irradiation and Solvent‐Free Conditions

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One‐Pot Preparation of Fluorinated α‐Aminoalkyl Phosphonates under Microwave Irradiation and Solvent‐Free Conditions

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