Sonochemical Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles in Aqueous Medium

Abstract

An ultrasound‐accelerated fast and efficient three‐component reaction for the regioselective synthesis of l,4‐disubstituted 1,2,3‐triazoles using different alkyl and allyl halides, terminal alkynes, and sodium azide in water at room temperature has been developed using CuI as catalyst. Ultrasonication dramatically decreases the reaction times.

Keywords:

• copper iodide
• 1,4‐disubstituted 1,2,3‐triazoles
• ultrasonication

Acknowledgments

PSR thanks the director, Indian Institute of Chemical Technology, Hyderabad, for providing facilities for carrying out his M. Tech. dissertation work. PSR also thanks the Council of Scientific and Industrial Research, New Delhi, for the award of Senior Research Fellowship.