Highly Efficient AILs/L‐Proline Synergistic Catalyzed Three‐Component Asymmetric Mannich Reaction

Abstract

A three‐component asymmetric Mannich reaction of isovaleraldehyde, methyl ketones, and aromatic amines was efficiently synergistic catalyzed by amide‐task‐specific ionic liquids (AILs)/L‐proline under mild conditions. The corresponding asymmetric Mannich reaction adducts were obtained in moderate to high yields and stereo selectivity in all the cases tested. The product was easily isolated, and the remaining catalysis system can be readily recovered and reused at least three times without significant loss of catalytic activity and selectivity.

Keywords:

• amide‐task‐specific ionic liquids (AILs)
• L‐proline
• Mannich reaction
• synergistic catalysis

Acknowledgment

This work was financially supported by the National Science Foundation of China (Project No. 20576026), State Key Laboratory Breeding Base of Green Chemistry–Synthesis Technology (Project No. 200402), and Science and Technology Office of HeBei Province (Project No. 04213036).