Abstract
The addition of TMSCN to aldehydes and ketones under microwave irradiation in the absence of any Lewis or Brønsted acid and solvent yielded the corresponding cyanohydrins in good yields in short reaction times (less than 30 min).
Acknowledgments
This work was supported in part by a Grant‐in‐Aid for Scientific Research (C, No. 18244120) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (to H. H.). This work was also supported in part by a Grant‐in‐Aid for Encouragement of Young Scientists (B, No. 16710157) from the Japan Society for the Promotion of Science (to H. I.). H. I. extends his gratitude to Sasakawa Scientific Research (Grant Nos. 6–182 and 7–199 K) and Sasakawa Grants for Science Fellows (No. F02–109) from the Japan Science Society for support his research. Finally, special grants from Chiba Institute of Science (Education and Research Grants in 2004 and 2006 to K. M. and H. I., respectively) are greatly acknowledged.