Synthesis of 4‐Substituted‐ and 1,4‐Disubstituted‐4‐Hydroxypyrrolidin‐2‐ones

Abstract

This report describes the synthesis of 4‐substituted‐ and 1,4‐disubstituted‐4‐hydroxypyrrolidin‐2‐ones by cyclization of intermediate γ‐aminoesters prepared from alkylbenzylamines, α‐bromoketones, and lithio ethyl acetate.

Keywords:

• cyclization
• γ‐lactams
• pyrrolidin‐2‐ones

Acknowledgments

The authors thank Wheaton College for financial support and Douglass A. Klumpp, Northern Illinois University, for mass spectral analysis.