α,α‐Dibromoketones: A Superior Alternative to α‐Bromoketones in Hantzsch Thiazole Synthesis

Abstract

α,α‐Dibromoketones (2) have been found to be a superior alternative to the conventionally used α‐bromoketones (1) for performing the Hantzsch thiazole synthesis.1 These crystalline, nonlachrymatory compounds are more reactive than 1 as demonstrated by their reaction with 3,5‐dimethyl‐1‐thiocarboxamide (5).

Keywords:

• 4‐aryl‐2‐(3,5‐dimethyl‐1‐pyrazolyl)thiazoles
• α‐bromoketones
• α,α‐dibromoketones
• 3,5‐dimethyl‐1‐thiocarboxamide

Acknowledgment

We are thankful to Defense Research and Development Organization (DRDO) (ERIP/ER/0103294), New Delhi, for the award of a junior research fellowship to Richa Prakash to carry out this work.