Synthesis of Piperidine Derivatives by Reduction of Pyridinium Salts

Abstract

Piperidine derivatives 1a–e and 2a–f have been prepared by the reduction of 3‐and 4‐substituted pyridinium salts with NaBH₄ in moderate to excellent yields. The reactions regioselectively give 1,2,5,6‐tetrahydropyridines, and the yields depend greatly upon the nature of substituents on the phenyl ring and on the nitrogen atom, the nature and the position of the substituents on the pyridyl ring, and the chain length between the aryloxy and the pyridyl groups.

Keywords:

• peperidine
• pyridinium salt
• reduction
• synthesis

Acknowledgment

We thank the EGIDE for financial support.