Graphical Abstracts

Abstract

Graphical Abstract Section

Abstract

Synth. Commun. 2007, 37, 2815

MICROWAVE‐ASSISTED ONE-POT SYNTHESIS OF 2-(SUBSTITUTED PHENYL)-1H-BENZIMIDAZOLE DERIVATIVES

Gabriel Navarrete-Vazquez,¹ Hermenegilda Moreno-Diaz,¹ Mariana Torres-Piedra,¹ Ismael León-Rivera,² Hugo Tlahuext,² Omar Muñoz-Muñiz,³ Hector Torres-Gómez,⁴ and Samuel Estrada-Soto¹

¹Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, México

²Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, México

³Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, México

⁴Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Cuernavaca, México

A simple, fast, and efficient method for the preparation of several benzimidazole derivatives is reported. Compounds were synthesized via microwave irradiation using a short synthetic route and solvent-free conditions.

Abstract

Synth. Commun. 2007, 37, 2827

NOVEL CYANOKETENE N,S-ACETALS AND PYRAZOLE DERIVATIVES USING POTASSIUM 2-CYANOETHYLENE-1-THIOLATES

Galal H. Elgemeie,¹ Ahmed H. Elghandour,² and Ghada W. Abd Elaziz²

¹Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt

²Chemistry Department, Faculty of Science, Cairo University, Beni-Suef Branch, Beni-Suef, Egypt

Novel keten N,S-acetals 3 were readily prepared by the reaction of activated nitriles 1a,b with phenylisothiocyanate in the presence of potassium hydroxide, followed by alkylation of the produced salts 2 with methyl iodide. The reaction of compounds 3 with hydrazines afforded difference substituted pyrazoles 6.

Abstract

Synth. Commun. 2007, 37, 2835

ASYMMETRIC INDUCTION THROUGH METALATION OF CHIRAL DITHIOACETALS AND OXTHIOACETALS

Javid. H. Zaidi and Naseem Iqbal Gunjial

Department of Chemistry, Quaid‐i‐Azam University, Islamabad, Islamabad, Pakistan

Abstract

Synth. Commun. 2007, 37, 2847

EFFICIENT AND INDUSTRIALLY VIABLE SYNTHESIS OF DONEPEZIL

R. Janaki Rama Rao,¹ A. K. S. Bhujanga Rao,¹ and Y. L. N. Murthy²

¹Natco Research Centre, Natco Pharma Ltd., Hyderabad, Andhra Pradesh, India

²Department of Organic Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India

Abstract

Synth. Commun. 2007, 37, 2855

SYNTHESIS OF (±)-AR-MACROCARPENE

A. Srikrishna and B. Beeraiah

Department of Organic Chemistry, Indian Institute of Science, Bangalore, India

Abstract

Synth. Commun. 2007, 37, 2861

EFFICIENT SYNTHESIS OF N-OXIDE DERIVATIVES: SUBSTITUTED 2-(2-(PYRIDYL-N-OXIDE)METHYLSULPHINYL)BENZIMIDAZOLES

Purna C. Ray, Vasantha Mittapelli, Amit Rohatgi, and Om Dutt Tyagi

Matrix Laboratories Limited, Medak Dist, India

Abstract

Synth. Commun. 2007, 37, 2869

IONIC LIQUID–PROMOTED STEREOSELECTIVE SYNTHESIS OF (Z)-VINYL BROMIDES BY [BMIM]OH UNDER ORGANIC SOLVENT–FREE CONDITIONS: A GREEN APPROACH

Brindaban C. Ranu, Subhash Banerjee, and Jhinuk Gupta

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadarpur, Kolkata, India

Abstract

Synth. Commun. 2007, 37, 2877

CYCLOPENTYL: A NOVEL PROTECTIVE GROUP FOR PHENOLS

Jitendra M. Gajera, Laxmikant A. Gharat, and Aniket V. Farande

Drug Discovery Chemistry, Glenmark Research Centre, Navi Mumbai, India

Abstract

Synth. Commun. 2007, 37, 2881

STANNIC CHLORIDE–IODINE: AN EFFICIENT REAGENT FOR REGIOSELECTIVE SYNTHESIS OF FURAN–FUSED HETEROCYCLES

K. C. Majumdar, A. Biswas, and P. P. Mukhopadhyay

Department of Chemistry, University of Kalyani, Kalyani, West Bengal, India

Abstract

Synth. Commun. 2007, 37, 2891

EFFICIENT SYNTHESIS OF TERT-BUTYL ETHERS UNDER SOLVENT-FREE CONDITIONS

Neithnadka Premsai Rai and Pirama Nayagam Arunachalam

Syngene International Pvt. Ltd., Bangalore, India

A simple and efficient synthesis of tert-butyl ethers from various alcohols and substituted phenols using tert-butyl bromide in the presence of basic lead carbonate as a catalyst. The catalyst is easily recovered via filtration and can be reused up to three times without appreciable loss of activity.

Abstract

Synth. Commun. 2007, 37, 2897

IMPROVED METHODS FOR THE SYNTHESIS OF IRBESARTAN, AN ANTIHYPERTENSIVE ACTIVE PHARMACEUTICAL INGREDIENT

Korrapati V. V. Prasada Rao,¹ Ramesh Dandala,¹ Vijay. K. Handa,³ Inti. V. Subramanyeswara Rao,¹ Ananta Rani,¹ and Andra Naidu²

¹Research and Development Department, Aurobindo Pharma Ltd, Hyderabad, Andhra Pradesh, India

²Jawaharlal Nehru Technological University, Hyderabad, India

Abstract

Synth. Commun. 2007, 37, 2907

REGIOSELECTIVE SYNTHESIS OF BENZOFURAN-ANNULATED SIX-MEMBERED SULFUR HETEROCYCLES BY ARYL RADICAL CYCLIZATION

K. C. Majumdar, B. Chattopadhyay, and S. Nath

Department of Chemistry, University of Kalyani, Kalyani, West Bengal, India

Abstract

Synth. Commun. 2007, 37, 2917

SYNTHESIS OF METAL-FREE PHTHALOCYANINES IN FUNCTIONALIZED AMMONIUM IONIC LIQUIDS

S. M. S. Chauhan, Shweta Agarwal, and Pratibha Kumari

Department of Chemistry, University of Delhi, Delhi, India

Cycloteramerization of varoius phthalonitriles in the presence of DBU in different hydroxyalkylammonium ionic liquids at 120–150°C gave metal-free phthalocyanines in moderate yields

Abstract

Synth. Commun. 2007, 37, 2927

PRACTICAL SYNTHESIS OF SUGAR MONOPHOSPHONUCLEOTIDES

Wjatschesslaw A. Wlassoff, Richard M. J. Finlay, and Chris J. Hamilton

School of Chemistry and Chemical Engineering, Queens University Belfast, Belfast, U.K.

A practical method is described for preparing purine- and pyrimidine-derived sugar monophosphonucleotides from accessible glycosyl-1-H-phosphonate precursors.

Abstract

Synth. Commun. 2007, 37, 2935

1,3-DIPOLAR CYCLOADDITIONS OF ALDEHYDES OR IMINES WITH CARBONYL YLIDES GENERATED FROM EPOXIDES: CLASSICAL HEATING AND MICROWAVE IRRADIATION.

Ghenia Bentabed,^1,3 Mustapha Rahmouni,² Florence Mongin,³ Aicha Derdour,¹ Jack Hamelin,⁴ and Jean Pierre Bazureau⁴

¹Laboratoire de Synthèse Organique Appliquée, Faculté des Sciences, Oran, Algérie

²Laboratoire de Synthèse Organique et Catalyse, Université Ibn Khaldoun, Tiaret, Algérie

³Synthèse and Electro Synthèse Organiqes, Université de Rennes 1, Rennes Cedex, France

⁴Sciences Chimiques de Rennes, Université de Rennes 1, Rennes Cedex, France

Abstract

Synth. Commun. 2007, 37, 2949

SYNTHESIS AND STRUCTURAL ELUCIDATION OF NOVEL BISARYLMETHYLIDENES OF CYCLIC ENONES

M. Saeed Abaee,¹ Mohammad M. Mojtahedi,¹ M. Mehdi Zahedi,¹ Roholah Sharifi,¹ A. Wahid Mesbah,¹ and Werner Massa²

¹Organic Chemistry Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran

²Fachbereich Chemie der Philipps-Universitaet Marburg, Marburg, Germany

The first procedure for the synthesis of novel bisarylmethylidenes of cyclohex-2-enone structures is described at room temperature using a mild medium consisting of anhydrous zinc bromide and triethylamine. Several compounds of this class are synthesized conveniently and rapidly. Spectroscopic and X-ray diffraction experiments confirm the proposed structures.

Abstract

Synth. Commun. 2007, 37, 2959

SYNTHESIS OF 5-CYANO-1,3-DIOXOALKANES BY REACTION OF 1,3-DICARBONYL DIANIONS WITH BROMOACETONITRILE

Edith Holtz¹ and Peter Langer^2,3

¹Institut für Organische Chemie, Georg-August-Universität Göttingen, Göttingen, Germany

²Institut für Chemie, Universität Rostock, Rostock, Germany

³Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Rostock, Germany

Abstract

Synth. Commun. 2007, 37, 2967

DABCO–BROMINE COMPLEX: A NOVEL OXIDIZING AGENT FOR OXIDATIVE DEPROTECTION OF THP AND SILYL ETHERS AND SEMICARBAZONES TO CORRESPONDING CARBONYL COMPOUNDS

Mahmood Tajbakhsh,¹ Majid M. Heravi,² and Setareh Habibzadeh^{1 1}Department of Chemistry, School of Sciences, Mazandaean University, Babolsar, Iran

²Department of Chemistry, School of Sciences, Azzáhero University, Vanak, Tehran, Iran

Abstract

Synth. Commun. 2007, 37, 2975

ASYMMETRIC SYNTHESIS AND CHARACTERIZATION OF CHIRAL 2,2′-DIAMINO-3,3′-DIETHOXYCARBONYL-8,8′-DIPHENYL-1,1′-BIAZULENE

Arh-Hwang Chen, Hsiu-Hang Yen Yu-Chen Kuo, and Wen-Zhang Chen

Department of Chemical and Materials Engineering, Southern Taiwan University of Technology, Yung-Kang City, Taiwan

Abstract

Synth. Commun. 2007, 37, 2989

CONCISE SYNTHESIS OF PENTENYL PHENYL ACRYLIC ACID

Dequn Sun,¹ Pengxiang Lai,¹ Weidong Xie,¹ Jingen Deng,² and Yaozhong Jiang²

¹Marine College, Shandong University at Weihai, China

²Chengdu Institute of Organic Chemistry, CAS, China

A new synthetic strategy was developed to prepare pentenyl phenyl acrylic acid 15, the important component of Pepticinnamin E, with high stereoselectivity and high overall yield of 78.6% in five step procedure.

Abstract

Synth. Commun. 2007, 37, 2995

SHORT AND EFFICIENT SYNTHESIS OF THIOLS GROUP FUNCTIONALIZED CROWN ETHER

Yong Sun,¹ Xiaoxia Lu,² Rui Wang,¹ Lin Shi,² and Bin Yang¹

¹Department of Chemistry, Sichuan University, Chengdu, P. R. China

²Chengdu Institute of Biology, Chinese Academic of Sciences Chengdu, P. R. China

Mercaptobenzocrown SH-B15C5 and SH-B18C6 (B15C5=Benzo-15-crown-5; B18C6= Benzo-18-crown-6) have been synthesized from direct chlorosulfonation of simple crown ether with chlorosulfonic acid and then reduction of the sulfonyl chloride moiety with LiAlH4. This work describes a short and efficient synthetic method for thiols group functionalized crown ethers.

Abstract

Synth. Commun. 2007, 37, 3003

HIGHLY EFFICIENT AILS/L‐PROLINE SYNERGISTIC CATALYZED THREE‐COMPONENT ASYMMETRIC MANNICH REACTION

Baoyou Liu,¹ Danqian Xu,² Jianfang Dong,¹ Huilong Yang,¹ Dishun Zhao,³ Shuping Luo,²and Zhenyuan Xu²

¹College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, China

²Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou, China

³College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China

A series of β‐amino ketones were prepared through asymmetric Mannich reaction of isovaleraldehyde, methyl ketones and aromatic amines synergistic catalyzed by AILs/L‐Proline with high yields and enantioselectivities under mild conditions.

Abstract

Synth. Commun. 2007, 37, 3011

SO₄ ²⁻/SNO₂: EFFICIENT, CHEMOSELECTIVE AND REUSABLE CATALYST FOR ACYLATION OF ALCOHOLS, PHENOLS, AND AMINES AT ROOM TEMPERATURE

Jitendra R. Satam, Manoj B. Gawande, Sameer S. Deshpande, and Radha V. Jayaram

Department of Chemistry, University Institute of Chemical Technology, Mumbai, India