Graphical Abstracts

Abstract

Graphical Abstract Section

Abstract

Synth. Commun. 2007, 37, 3273

FACILE SYNTHESIS OF BIBENZYL BY REDUCTIVE HOMOCOUPLING OF BENZYL HALIDES IN AQUEOUS MEDIA

Jian Liu and Bin Li

Department of Chemistry, Beijing Normal University, Beijing, China

A convenient and efficient synthesis of bibenzyl derivatives by reductive homocoupling reaction of benzyl halides using metallic iron powder in the presence of a catalytic amount of cuprous salt in water is described, which gives bibenzyl derivatives in good yields.

Abstract

Synth. Commun. 2007, 37, 3279

COPPER–FREE, EFFICIENT, PALLADIUM(II)–CATALYZED COUPLING OF UNACTIVATED ARYL IODIDES WITH TERMINAL ALKYNES

Tianrui Ren, Ye Zhang, Weiwen Zhu, and Jiaju Zhou

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China, and Graduate University of Chinese Academy of Sciences, Beijing, China

Palladium–catalyzed Sonogashira cross–coupling of unactivated aryl iodides with terminal alkynes.

Abstract

Synth. Commun. 2007, 37, 3291

ONE–POT DIRECT SYNTHESIS OF THIOCARBAMATES FROM ANILINE, CARBON MONOXIDE, AND THIOLS CATALYZED BY SELENIUM

Xiaopeng Zhang^1,2 and Shiwei Lu²

¹College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, China

²National Engineering Research Center for Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

A mild and convenient method for the direct synthesis of thiocarbamates from aniline, carbon monoxide, and thiols catalyzed by selenium.

Abstract

Synth. Commun. 2007, 37, 3301

EUROPIUM TRIFLATE–CATALYZED ONE–POT SYNTHESIS OF 2,4,5–TRISUBSTITUTED–1H–IMIDAZOLES VIA A THREE–COMPONENT CONDENSATION

Chuanming Yu, Min Lei, Weike Su, and Yuanyuan Xie

College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou, China

A simple, efficient, and practical procedure for the condensation of benzoin or acetoin, aromatic aldehydes, and ammonium acetate using europium triflate [Eu(OTf)₃] as a novel catalyst in high yields is described. The catalyst can be recovered conveniently and reused at least four times without any loss of activity.

Abstract

Synth. Commun. 2007, 37, 3311

TOTAL SYNTHESIS OF NEUROPROTECTIVE DICTYOQUINAZOL A, B, AND C

Chang Ho Oh and Chung Hyun Song

Department of Chemistry, Hanyang University, Sungdong–Gu, Seoul, Korea

A new protective compound, dictyoquinazol A, was synthesized starting from 5–methoxy–2–nitrobenzoic acid in six steps in 36% overall yield. Two derivatives B and C, isolated from the mushroom Dictyophora indusiata, were also synthesized from Dictyoquinazole A.

Abstract

Synth. Commun. 2007, 37, 3319

STUDY ON THE SYNTHESIS AND BIOACTIVITY OF NOVEL MAHKOSIDE A DERIVATIVES

Yan–Bing Zhang, Pi–Yong Zhang, Gui–Fu Dai, and Hong–Min Liu

Department of Chemistry, New Drug Research and Development Center, Zhengzhou University, Zhengzhou, China

A series of novel Mahkoside A derivatives was reported, and the structure–activity relationship was analyzed.

Abstract

Synth. Commun. 2007, 37, 3329

SOLVENT–FREE SYNTHESIS OF BENZOTHIAZOLINES IN THE PRESENCE OF ALUMINA

Mitsuo Kodomari,¹ Akihito Satoh,¹ Ryo Nakano,¹ and Tadashi Aoyama²

¹Department of Applied Chemistry, Shibaura Institute of Technology, Koto–ku, Tokyo, Japan

²Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda–ku, Tokyo, Japan

Abstract

Synth. Commun. 2007, 37, 3337

EXPEDITIOUS SYNTHESIS OF NEW 3,4,6–TRIHYDROXYTHIEPANES FROM D–(–)–QUINIC ACID

Tzenge–Lien Shih and Yi–Chuan Fang

Department of Chemistry, Tamkang University, Tamsui, Taipei County, Taiwan, Republic of China

Abstract

Synth. Commun. 2007, 37, 3351

SCANDIUM TRIFLATE–PROMOTED ADDITION OF ORGANOZINC REAGENTS TO BENZALDIMINETRICARBONYLCHROMIUM DERIVATIVES

Kaori Ishimaru, Kyoto Ohe, and Takakazu Kojima

Department of Chemistry, National Defense Academy, Hashirimizu, Yokosuka, Japan

Abstract

Synth. Commun. 2007, 37, 3359

P D/C: A RECYCLABLE CATALYST FOR CYANATION OF ARYL HALIDES WITH K₄[FE(CN)₆]

Yi–Zhong Zhu and Chun Cai

Chemical Engineering College, Nanjing University of Science and Technology, Nanjing, China

Abstract

Synth. Commun. 2007, 37, 3367

SYNTHESIS OF PIPERIDINE DERIVATIVES BY REDUCTION OF PYRIDINIUM SALTS

Zilong Tang,^1,2 Joelle Mayrargue,¹ and Mouad Alami²

¹Faculty of Pharmacy, Department of Chemistry, University of Paris–Sud, Chatenay–Malabry Cedex, France

²School of Chemistry and Chemical Engineering, Hunan Provincial University Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan, China

A series of unsaturated piperidines was prepared in moderate to excellent yields by the reduction of the corresponding pyridinium salts with NaBH₄ in methanol.

Abstract

Synth. Commun. 2007, 37, 3381

CE(SO₄)₂–MEDIATED NITRATION OF N,N–DIALKYLANILINES WITH NANO₂ IN WATER

Xianghua Yang and Chanjuan Xi

Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China

Abstract

Synth. Commun. 2007, 37, 3393

PRACTICAL SYNTHESIS OF NEW β‐ DIKETONE‐CONNECTED BIPYRIDINE AND ITS CONVERSION TO PYRAZOLE‐CENTERED BIPYRIDINE LIGAND

Wei Zhang,¹ Jianhui Liu,¹ Hongjun Zhu,¹ Weiming Gao,¹ and Licheng Sun^1,2

¹State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China

²Department of Chemistry, Organic Chemistry, Royal Institute of Technology (KTH), Stockholm, Sweden

Abstract

Synth. Commun. 2007, 37, 3403

EFFICIENT AND CONVENIENT ONE–POT, SYNTHESIS OF PHOSPHORAMIDATES AND PHOSPHATES

A. K. Gupta, J. Acharya, D. K. Dubey, and M. P. Kaushik

Process Technology Development Division, Defence Research and Development Establishment, Gwalior, India

Abstract

Synth. Commun. 2007, 37, 3409

IMPROVED SYNTHESIS OF GEFITINIB AND ERLOTINIB HYDROCHLORIDE– ANTICANCER AGENTS

Venkateshappa Chandregowda, Gudapati Venkateswara Rao, and Goukanapalli Chandrasekara Reddy

Vittal Mallya Scientific Research Foundation, Bangalore, India

Abstract

Synth. Commun. 2007, 37, 3417

RAPID, CHEMOSELECTIVE AND FACILE SYNTHESIS OF AZINES BY HYDRAZINE/I₂

H. M. Nanjundaswamy¹ and M. A. Pasha²

¹Chemical Examination Section, Public Health Institute, Bangalore, India

²Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India

We report the reaction of hydrazine hydrate with carbonyl compounds in the presence of molecular iodine at 0–10°C, which affords symmetrical azines in excellent yields in 1 to 4 min without any adverse effect on other substituents. The reactions are rapid and chemoselective, afford excellent yields, and have high–purity products. The workup procedure is environmentally benign and does not require solvent extraction.

Abstract

Synth. Commun. 2007, 37, 3421

REGIOSELECTIVE PHOTOCHEMICAL AND MICROWAVE–MEDIATED MONOBROMINATION OF AROMATIC COMPOUNDS USING 2,4,4,6–TETRABROMO–2,5–CYCLOHEXADIENONE

Neeraj Gupta,¹ Goverdhan L. Kad,¹ Vasundhara Singh,² and Jasvinder Singh¹

¹Department of Chemistry, Punjab University, Chandigarh, India

²Department of Applied Sciences, Punjab Engineering College (Deemed University), Chandigarh, India

Abstract

Synth. Commun. 2007, 37, 3429

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1–[(SUBSTITUTED CARBAMOYL)AMINO] –1H,3H–1λ⁵–[1,3,2] OXAZAPHOSPHOLO[3,4–A] BENZIMIDAZOL–1–ONES

U. Anasuyamma, P. Haranath, M. Anil Kumar, C. Suresh Reddy, and C. Naga Raju

Department of Chemistry, Sri Venkateswara University College of Engineering, Tirupati, India

1–[(Substituted carbamoyl)amino] –1H,3H–1λ⁵–[1,3,2] oxazaphospholo[3,4–a] benzim–idazol–1–ones (5a–j) were synthesized by reacting benzimidazole 2–methanol (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40–45°C. Their ¹H, ¹³C, and ³¹P NMR spectral data were discussed. The title compounds were tested for their activity against the fungi Aspergillus niger and Fusarium solani and bacteria Staphylococcus aureus and Escherichia coli. These compounds showed moderate antibacterial activity when compared with antifungal activity.

Abstract

Synth. Commun. 2007, 37, 3439

EFFICIENT SYNTHESIS OF (1R)–[3,5–BIS(TRIFLUOROMETHYL)PHENYL] ETHANOL, A KEY INTERMEDIATE FOR APREPITANT, AN NK–1 RECEPTOR ANTAGONIST

Pravinchandra J. Vankawala,¹ Naveenkumar Kolla,¹ Chandrashekar R. Elati,¹ M. Sreenivasulu,² K. Arun Kumar,² Yerrimilli Anjaneyulu,³ Sundaram Venkatraman,¹ Apurba Bhattacharya,¹ and Vijayavitthal T. Mathad¹

¹Research and Development, Dr. Reddy's Laboratories Ltd., Bollaram, India

²Department of Custom Chemical Service, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, Andhra Pradesh, India

³Center for Atmospheric Science, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh, India

Abstract

Synth. Commun. 2007, 37, 3447

EFFICIENT AND GREEN METHOD FOR THE SYNTHESIS OF 1,5–BENZODIAZEPINE AND QUINOXALINE DERIVATIVES IN WATER

Parasa Hazarika, Pranjal Gogoi, and Dilip Konwar

Synthetic Organic Chemistry Division, Regional Research Laboratory, Jorhat, Assam, India

Abstract

Synth. Commun. 2007, 37, 3455

EFFICIENT METHOD FOR THE SYNTHESIS OF BENZIMIDAZOQUINAZOLINE DERIVATIVES WITH THREE–POINT DIVERSITY

Biswajit Saha, Sunil Sharma, and Bijoy Kundu

Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India