Synthesis of New Tetrazole Derivatives of α,α‐Trehalose

Leandro J. dos Santos Departamento de Química—Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilCorrespondence[email protected]

Mara R. C. Couri Departamento de Química—Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Inácio Luduvico Departamento de Química—Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Rosemeire B. Alves Departamento de Química—Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Maria A. F. Prado Departamento de Química Farmacêutica—Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Rossimiriam P. Freitas Gil Departamento de Química—Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Abstract

Five new nitrogen heterocycles, mono‐and disubstituted tetrazoles with potential synthetic and pharmacological interest, were synthesized from α, α‐trehalose via the alkylation of commercial tetrazoles. This method appears to have broad scope with respect to the variations at positions 1 and 2 of tetrazole.

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Acknowledgments

The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the fellowships.

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Synthesis of New Tetrazole Derivatives of α,α‐Trehalose

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Synthesis of New Tetrazole Derivatives of α,α‐Trehalose

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