Convenient Formal Synthesis of (±)‐Paroxetine

Subhash P. Chavan Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, IndiaCorrespondence[email protected]

Dushant A. Khobragade Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India

Ashok B. Pathak Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India

Uttam R. Kalkote Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India

Abstract

A formal total synthesis of antidepressant (±)‐paroxetine employing a solvent‐free Heck reaction is disclosed.

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Acknowledgments

D. A. K. and A. B. P. thank Council for Scientific and Industrial Research (CSIR), New Delhi, India, for providing fellowships. We are grateful to Shinji Yamada and C. R. D. Correia for kindly providing spectral data of the authentic samples.

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Convenient Formal Synthesis of (±)‐Paroxetine

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Convenient Formal Synthesis of (±)‐Paroxetine

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