Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐c]quinazoline System

Sergey I. Kovalenko Department of Pharmaceutical Chemistry, Zaporozhye State Medical University, Zaporozhye, Ukraine

Alexander V. Karpenko Department of Pharmaceutical Chemistry, Zaporozhye State Medical University, Zaporozhye, UkraineCorrespondence[email protected]

Oksana V. Krivoshey Department of Pharmaceutical Chemistry, Zaporozhye State Medical University, Zaporozhye, Ukraine

Svetlana V. Shishkina STC Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkov, Ukraine

Oleg V. Shishkin STC Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkov, Ukraine

Abstract

4‐Hydrazinoquinazoline was found to form new 2‐(3,4‐dihydro‐3oxo‐2H‐[1,2,4]triazino[4,3‐c]quinazolin‐4‐yl)acetic acid with maleic anhydride in on‐step sequence. Proposed heterocyclization includes, probably, acylation reaction followed by intramolecular uncleophilic addition.

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Acknowledgments

We are grateful to Enamine Ltd. (Kiev, Ukraine) for the financial support of this work.

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Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐c]quinazoline System

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Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐c]quinazoline System

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