Synthesis and Biological Evaluation of New 4‐Deacety‐1,7,9‐trideoxy‐10‐oxopaclitaxel via Sinenxan A

Huixia Du Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China

Meng Zhang Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China

Dali Yin Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaCorrespondence[email protected]

Yan Li Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China

Xiaoguang Chen Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China

Abstract

A new 4‐deacety‐1,7,9‐trideoxy‐10‐oxopaclitaxel (compound 1) was prepared in 21 steps via sinenxan A, a biosynthetic taxane. The biological evaluation in vitro against human cancer lines showed compound 1 to be devoid of cytotoxicity.

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Acknowledgments

This authors gratefully acknowledge financial supported of this work by National Natural Science Foundation of China (Project No. 30572243) and Beijing Natural Science Foundation (Project No. 7062048). We thank Jungui Dai for kindly providing Sinenxan A (SIA).

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Synthesis and Biological Evaluation of New 4‐Deacety‐1,7,9‐trideoxy‐10‐oxopaclitaxel via Sinenxan A

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Synthesis and Biological Evaluation of New 4‐Deacety‐1,7,9‐trideoxy‐10‐oxopaclitaxel via Sinenxan A

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