Syntheses of Some Sulfur‐Containing Polyunsaturated Fatty Acids as Potential Lipoxygenase Inhibitors

Abstract

Starting from (all‐Z)‐eicosa‐5,8,11,14,17‐pentaenoic acid (EPA) and (all‐Z)‐4,7,10,13,16,19‐docosahexaenoic acid (DHA), several polyunsaturated fatty acids, containing a sulfur atom either in the chain or in a thiophene ring, have been synthesized as potential inhibitors of lipoxygenases.

Keywords:

• polyunsaturated fatty acids
• sulfur-containing fatty acids
• 5-lipoxygenase
• dicyclohexylborane