Synthesis of 1,8‐Naphthyridine‐4(1H)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative

Luiz Everson da Silva Department of Chemistry, Federal University of Mato Grosso State (UFMT), Cuiabá, MT, BrazilCorrespondenceluiz_everson@yahoo

Antonio Carlos Joussef Department of Chemistry, Federal University of Santa Catarina State (UFSC), Florianópolis SC, Brazil

Ricardo José Nunes Department of Chemistry, Federal University of Santa Catarina State (UFSC), Florianópolis SC, Brazil

Kely Navakoski de Oliveira Department of Chemistry, Federal University of Santa Catarina State (UFSC), Florianópolis SC, Brazil

Abstract

An efficient synthesis of 1,8‐naphthyridine‐4(1H)‐one sulfonamide derivatives by thermolysis of 2‐pyridylaminomethylene (Meldrum's acid derivative) starting from 4,6‐dimethyl‐2‐aminopyridine (1) is described.

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Acknowledgment

The authors are indebted to Capes (Brazil) and Brazilian Research Council (CNPq) for financial support of this work.

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Synthesis of 1,8‐Naphthyridine‐4(1H)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative

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Synthesis of 1,8‐Naphthyridine‐4(1H)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative

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