Graphical Abstracts

Graphical Abstract Section

Abstract

Synth. Commun. 2006, 36, 8

CONVENIENT PREPARATION OF 2,7,8-TRIMETHYL-6-HYDROXYCHROMAN-2-CARBOXYLIC ACID (γ-TROLOX)

John A. Hyatt

Department of Chemistry, East Tennessee State University, Johnson City, Tennessee, USA and Yasoo Health, Inc., Johnson City, Tennessee, USA

Abstract

Synth. Commun. 2006, 36, 15

SYNTHESIS OF 1,8-NAPHTHYRIDINE-4(1H)-ONE SULFONAMIDE BY THERMOLYSIS OF 2-AMINOPYRIDINEMETHYLENE (MELDRUM'S ACID) DERIVATIVE

Luiz Everson da Silva,¹ Antonio Carlos Joussef,² Ricardo José Nunes,² and Kely Navakoski de Oliveira²

¹Department of Chemistry, Federal University of Math Grosso State (UFMT), Cuiabá, MT, Brazil

²Department of Chemistry, Federal University of Santa Catarina State (UFSC), Florianópolis SC, Brazil

An efficient synthesis of 1,8-naphthyridine-4(1H)-one sulfonamide derivatives by thermolysis of 2-pyridylaminomethylene (Meldrum's acid derivative) starting from 4,6-dimethyl-2-aminopyridine (1) is described.

Abstract

Synth. Commun. 2006, 36, 21

SELECTIVE MONOARYLATION OF BENZENEDIOLS VIA DIANION INTERMEDIATES

Chaoyu Xie, Kevin A. Sullivan, Michael E. Laurila, David N. Mitchell, and Y. John Pu

Lilly Research Laboratories, Chemical Product Research and Development, Indianapolis, Indiana, USA

Application of the S_NAr reaction on benzenediols with arylfluorides revealed an enhancement in monosubstitution selectivity over bis substitution when excess base was used. This trend was studied using symmetrical and nonsymmetrical benzenediols with various levels of steric hindrance. The effect of various bases was examined. A 100% monoselectivity was achieved in the presence of 2.5 equiv. of Cs₂CO₃. The methodology was employed in the synthesis of an important pharmaceutical product, 1, an arylether.

Abstract

Synth. Commun. 2006, 36, 33

N‐FORMAMIDO‐CONTAINING MONO‐ AND DIHETEROCYCLIC PYRROLE‐AND IMIDAZOLE‐2‐CARBOXYLIC ACIDS AS BUILDING BLOCKS FOR POLYAMIDE SYNTHESIS

Keith Mulder¹, Jim Sexton², Zarmeen Taherbhai², Justin Jones², Peter Uthe², Toni Brown^1,2, and Moses Lee^1,2

¹Division of Natural Sciences and Department of Chemistry, Hope College, Holland, MI, USA

²Department of Chemistry, Furman University, Greenville, USA

Abstract

Synth. Commun. 2006, 36, 45

SYNTHESIS OF Z-N-ALKENYLFORMAMIDES

Lucina G. Sánchez, Ratnasamy Somanathan, Lars H. Hellberg, and Gerardo Aguirre

Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Tijuana, México

This article describes the synthesis of Z-N-alkenylformamides 11Z and 12Z in 18 and 34% yield, respectively.

Abstract

Synth. Commun. 2006, 36, 54

STEREOSELECTIVE SYNTHESIS OF RUBRENOIC AND NOR-RUBRENOIC ACIDS

L. G. Sánchez, E. N. Castillo, H. Maldonado, D. Chávez, R. Somanathan, and G. Aguirre

Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Tijuana, México

We have developed a stereoselective synthetic route to (Z)-rubrenoic and nor-(Z)-rubrenoic acids I and (E)-rubrenoic and nor-(E)-rubrenoic acids III.

Abstract

Synth. Commun. 2006, 36, 72

A CONVENIENT AND EFFICIENT PREPARATION OF 2-ACETYL-4,5-DIFLUOROTHIOPHENE

Gaifa Lai and Tao Guo

Pharmacopeia, Inc., Princeton, New Jersey, USA

Abstract

Synth. Commun. 2006, 36, 77

CERIUM (IV) TRIFLATE CATALYZED SELECTIVE GEM-DIACETYLATION OF ALDEHYDES WITH ACETIC ANHYDRIDE

J. W. John Bosco and Anil K. Saikia

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, India

It has been observed that catalytic amount (0.1 mol%) of cerium (IV) triflate afforded geminal diacetates from aldehydes with acetic anhydride in toluene at ambient temperature. Ketones are not affected under these reaction conditions. The reaction is rapid and mild with good to high yields.

Abstract

Synth. Commun. 2006, 36, 85

SYNTHESIS OF NEW BENZOXAZAPHOSPHININE/BENZOXAZAPHOSPHOLE/DIAZAPHOSPHAPHENALENE-2-SULFIDES USING LAWESSON'S REAGENT

G. Syam Prasad, B. Hari Babu, C. Devendranath Reddy, C. Naga Raju, and C. Suresh Reddy

Department of Chemistry, Sri Venkateswara University, Tirupati, India

Abstract

Synth. Commun. 2006, 36, 92

SYNTHESIS OF CHLOROESTERS BY THE CLEAVAGE OF CYCLIC AND ACYCLIC ETHERS USING LA(NO₃)₃ · 6H₂O AS A MILD AND EFFICIENT CATALYST UNDER SOLVENT-FREE CONDITIONS

V. Suresh, N. Suryakiran, K. Rajesh, J. Jon Paul Selvam, M. Srinivasulu, and Y. Venkateswarlu

Natural Products Laboratory, Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad, India

Abstract

Synth. Commun. 2006, 36, 100

SILICA SULFURIC ACID–CATALYZED FRIEDEL–CRAFTS ALKYLATION OF INDOLES WITH NITRO OLEFINS

G. Sri Hair, M. Nagaraju, and M. Marthanda Murthy

Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad, India

Abstract

Synth. Commun. 2006, 36, 106

RUCL₃ · XH₂O: A NEW EFFICIENT CATALYST FOR FACILE PREPARATION OF 1,1-DIACETATES FROM ALDEHYDES

Anil Saini, Sanjay Kumar, and Jagir S. Sandhu

Department of Chemistry, Punjabi University, Patiala, Punjab, India

An efficient, facile preparation of aldehyde 1,1-diacetates (acylals) in excellent yields catalyzed by RuCl₃ · xH₂O is described. Ketones do not react under these conditions.

Abstract

Synth. Commun. 2006, 36, 114

SYNTHESIS, OF SOME NOVEL 1,3,4-OXADIAZOL-2-YL-4(3H)-QUINAZOLINONES

A. Komaraiah, B. Sailu, and P. S. N. Reddy

Department of Chemistry, Osmania University, Hyderabad, India

Abstract

Synth. Commun. 2006, 36, 122

EXPEDIENT SYNTHESIS OF RUPATADINE

Rajendra Agarwal, Shekhar Bhaskar Bhirud, Gopinathenpillai Bijukumar, and Gopal Dnyandev Khude

Macleods Pharmaceuticals Ltd., Mumbai, India

Abstract

Synth. Commun. 2006, 36, 128

AN EFFICIENT METHOD FOR THE SYNTHESIS OF ACYLALS FROM ALDEHYDES UNDER SOLVENT-FREE CONDITIONS CATALYZED BY ANTIMONY TRICHLORIDE

Asish K. Bhattacharya, Mohammad Mujahid, and Arvind A. Natu

Combi Chem-Bio Resource Centre and Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India

A mild and efficient, and expeditious method has been developed for the preparation of acylals from the corresponding aldhydes in excellent yields, using acetic anhydride catalyzed by antimony trichloride.

Abstract

Synth. Commun. 2006, 36, 135

HETEROPOLYACIDS AS GREEN AND REUSABLE CATALYSTS FOR THE SYNTHESIS OF ISOXAZOLE DERIVATIVES

Majid M. Heravi,¹ Fatemeh Derikvand,¹ Anahita Haeri,¹ Hossein A. Oskooie,¹ and Fatemeh F. Bamoharram²

¹Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

²Department of Chemistry, Azad University of Mashhad, Mashad, Iran

Abstract

Synth. Commun. 2006, 36, 141

HIGHLY REGIOSELECTIVE BROMINATION OF BINAP IN [HMIM]PF₆ IONIC LIQUID

Mohammad Alamé,¹ Mohammad Jahjah,² Stéphane Pellet-Rostaing,² Marc Lemaire,² Valérie Meille,¹ M. Berthod,² and Claude De Bellefon

¹Laboratoire de Génie des Procédés Catalytiques, Université de Lyon, Université Claude Bernard, Villeurbanne Cedex, France

²ICBMS, Institut de chimie et Biochimie Moléculaire et Supramoléculaire, Université de Lyon, Université Claude Bemard, Vileurbanne Cedex, France

Abstract

Synth. Commun. 2006, 36, 148

FACILE AND CONVENIENT SYNTHESIS OF 1-PERFLUOROALKYL-1,2,4-TRIAZOLES

M. Kammoun,¹ A. Chihi,¹ B. Hajjem,¹ and M. Bellassoued²

¹Laboratoire de Chimie Organique, Institut National Agronomique de Tunisie, Tunis-Mahragène, Tunisia

²Laboratoire de Synthèse Organométallique, Cergy-Pontoise Cedex, France