Abstract
Δ 4-Isoxazoline derivatives were synthesized in excellent yields via the titanium tetrachloride–catalyzed 1,3-dipolar cycloaddition reaction of nitrones with α,β-unsaturated compounds under neat conditions at room temperatures in very short reaction time.
ACKNOWLEDGMENT
The partial financial assistance from the research vice chancellor of Azerbaijan University of Tarbiat Moallem is gratefully acknowledged.
Notes
a 15 mmol nitrone with 15 mmol DMAD.
b Molar ratio of catalyst to nitrone.
c Isolated yields by flash chromatography for entries 2–7 and by GC for entry 1.
a 15 mmol nitrone with 15 mmol DMAD.
b Isolated yields after flash chromatography for entries 1–10 and by GC for entries 11 and 12.