Novel One-Pot Synthesis for 2,5-Diaryl and 5-Aryl-pyridazin-3(2H)-ones

Abstract

A novel method for the synthesis of 2-phenyl-5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones and 5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones has been found during the reaction of 4-bromomethylcoumarins with phenylhydrazine and hydrazinehydrate, respectively, under controlled alkaline conditions.

Keywords:

• Coumarin
• diphenyl
• heterocycle
• hydrazinehydrate
• phenylhydrazine
• pyridazinone

ACKNOWLEDGMENTS

The authors are thankful to the University Sophisticated Instrumentation Centre (USIC), Karnatak University, Dharwad, for providing spectral and analytical data. One of us (Mahantesha Basanagouda) grateful to Karnatak University, Dharwad, for a university research studentship.