Synthesis of N-Substituted Carbonylamino-1,2,3,6-tetrahydropyridines as Potential Anti-Inflammatory Agents

Abstract

Several N-substituted carbonyl/sulfonylamino-1,2,3,6-tetrahydropyridines (5a–i and 9a, b) were synthesized via sodium borohydride reduction of the corresponding N-substitutedimino-pyridinium ylides (4a–i and 8a, b) in absolute ethanol.

Keywords:

• Inflammation
• tetrahydropyridine (THP)

ACKNOWLEDGMENTS

We are grateful to the National Institute of Health, the National Institute of General Medical Sciences, Research Center at Minority Institutions Grant (RCMI) RR 03020, and Pharmaceutical Research Center NIH/NCRR Grant 1 C06RR12512-01.