Solvent-Free C-Benzoylation and N-Benzoylation Reactions Using Microwave Heating

Abstract

An ecofriendly and efficient microwave-irradiated solvent-free benzoylation method was developed. The procedure for C-benzoylation used 50 mol% AlCl₃ as a Lewis acid catalyst at 130 °C and was completed in 10 min. The isolated yield was between 71% and 100%. N-benzoylation was conducted in a catalyst-free environment at 130 °C in 10 min. The isolated yield was between 80% and 100%.

Keywords:

• Catalyst-free and solvent-free N-benzoylation
• microwave heating
• solvent-free AlCl₃-catalyzed C-benzoylation

ACKNOWLEDGMENT

Financial support from U.S. Department of Education Title III grant to Tennessee State University is acknowledged.

Notes

^a All reactions were run at least two times. The products were purified by silica-gel chromatography using hexane/ethyl acetate (50/1) as the eluent.

^a All reactions were run at least two times. The products were purified by silica-gel chromatography using hexane/ethyl acetate (5/1) as the eluent.