Highly Efficient Synthesis of 3,5-Diaryl-1,2,4-thiadiazoles in Water–Wet Paste Conditions

Abstract

1,3-Dibromo-5,5-diphenylimidazolidine-2,4-dione (N,N’-dibromo phenytoin) was efficiently used for the rapid conversion of thiobenzamides to the corresponding 3,5-diaryl-1,2,4-thiadiazoles in water–wet paste conditions.

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Keywords:

• Green chemistry
• solvent-free
• thiadiazole
• thioamide

ACKNOWLEDGMENT

We are grateful to the University of Isfahan Research Council for financial support of this work.

Notes

^a All products were characterized by ¹H NMR, ¹³C NMR, and elemental analysis.

^b All yields refer to pure isolated products.