Synthesis of Heterocyclic Compounds Using Amidines as Their Ene-1,1-diamine Tautomers, IV: Synthesis of N-Bridged Heterocycles 1,2,3,4-Tetrahydropyrido[1,2-a]pyrimidin-6-ones and Methyl 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrimidin-7-ylideneacetates

Shogo Ihara Department of Applied Chemistry, Faculty of Science and Engineering, and Bio-Nano Electronics Research Center, Toyo University, Kujirai, Kawagoe, Saitama, JapanCorrespondence[email protected]

Takashi Soma Department of Applied Chemistry, Faculty of Science and Engineering, and Bio-Nano Electronics Research Center, Toyo University, Kujirai, Kawagoe, Saitama, Japan

Daigo Yano Department of Applied Chemistry, Faculty of Science and Engineering, and Bio-Nano Electronics Research Center, Toyo University, Kujirai, Kawagoe, Saitama, Japan

Shunichi Aikawa Department of Applied Chemistry, Faculty of Science and Engineering, and Bio-Nano Electronics Research Center, Toyo University, Kujirai, Kawagoe, Saitama, Japan

Yasuhiko Yoshida Department of Applied Chemistry, Faculty of Science and Engineering, and Bio-Nano Electronics Research Center, Toyo University, Kujirai, Kawagoe, Saitama, Japan

Abstract

2-Benzyl-1,4,5,6-tetrahydropyrimidines 1 (as ene-1,1-diamine N,C-tautomers) in diglyme reacted with ethyl benzoylacetate at 160 °C in an oil bath to give 1,2,3,4-tetrahydropyrido[1,2-a]pyrimidin-6-ones 3 and with dimethyl acetylenedicarboxylate in methanol at room temperature, leading to methyl 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrimidin-7-ylideneacetates 5, respectively.

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Synthesis of Heterocyclic Compounds Using Amidines as Their Ene-1,1-diamine Tautomers, IV: Synthesis of N-Bridged Heterocycles 1,2,3,4-Tetrahydropyrido[1,2-a]pyrimidin-6-ones and Methyl 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrimidin-7-ylideneacetates

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Synthesis of Heterocyclic Compounds Using Amidines as Their Ene-1,1-diamine Tautomers, IV: Synthesis of N-Bridged Heterocycles 1,2,3,4-Tetrahydropyrido[1,2-a]pyrimidin-6-ones and Methyl 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrimidin-7-ylideneacetates

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