Trifluoroethanol as a Metal-Free, Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones

Abstract

Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.

GRAPHICAL ABSTRACT

Keywords:

• Biginelli reaction
• cyclization
• homogeneous catalysis
• multicomponent
• trifluoro ethanol

ACKNOWLEDGMENTS

K. S. R. Acknowledges the University Grants Commission (phase 2) vide No. F. 540/10/2004-05 (SAP II) and the Department of Science and Technology–Funding for Infrastructure in Science and Technology program.

Notes

^a Yields refer to those of pure isolated products characterized by IR, ¹H NMR, LCMS, and elementary analysis.