Abstract
An efficient procedure for the preparation of aryl azides using sonication is described. The convenient sonication-mediated azidation protocol is applicable to aryl compounds under mild conditions with aqueous solution of sodium dichloroiodate and sodium azide. Aryl azides were obtained in excellent yields from a variety of aryl compounds in short reaction times without affecting sensitive functional groups.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENT
K. A. S. gratefully acknowledges the Council of Scientific and Industrial Research, Delhi, India, for financial support.
Notes
a Reaction conditions: Substrate (1.0 equiv), aqueous solution of sodium dichloroiodate (1.5 M, 1.01 equiv), and sodium azide (1.01 equiv) at room temperature combined with sonication.
b Starting compounds were prepared by standard reported procedures.
c Isolated yields after column chromatography and structures were confirmed by comparison of the IR and 1H NMR spectra with those of authentic materials.[ Citation 3 , Citation 4 , Citation20-22 ]
d No reaction.