Tetrakis(acetonitrile)copper(I) Hexafluorophosphate–Promoted Efficient Synthesis of Amidoalkyl Naphthols Under Solvent-Free Conditions

Abstract

An efficient and direct protocol for the preparation of amidoalkyl naphthols employing a multicomponent, one-pot condensation reaction of β-naphthol, aromatic aldehydes, and amides (acetamide, benzamide, and urea) in the presence of tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu(CH₃CN)₄PF₆] under solvent-free conditions at 80 °C is described. Good yields, short reaction time, and easy workup are advantages of this procedure.

GRAPHICAL ABSTRACT

Keywords:

• Amidoalkyl naphthols
• Cu(CH₃CN)₄PF₆
• multicomponent reaction
• β-naphthol
• solvent-free

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of Razi University.