One-Pot Conversion of Aldehyde Sodium Bisulfites into Nitriles

Abstract

Direct conversion of aldehyde sodium bisulfites to the corresponding nitriles can be easily performed by the reaction of an aldehyde sodium bisulfites with a slight execss of hydroxylamine hydrochloride in refluxing toluene and in the presence of 1.0 equivalents of pyridine as catalyst.

GRAPHICAL ABSTRACT

Keywords:

• Aldehyde sodium bisulfite
• hydroxylamine hydrochloride
• nitriles

Notes

^a The products were characterized by comparison of their mp or bp, TLC, IR, and ¹H NMR data with those of authentic samples.

^b Yields of pure compounds after distillation or recrystallization.

^a Reaction conditions: phenylacetaldehyde sodium bisulfite (10 mmol), hydroxylamine hydrochloride (11 mmol), 12 h.

^b Isolated yield.