Synthesis of N-Substituted Pyrroles Under Catalyst- and Solvent-Free Conditions

Abstract

N-Substituted pyrroles were synthesized under neat conditions by the reaction of aromatic amines with 2, 5-dimethoxytetrahydrofuran in excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Aromatic amines
• catalyst- and solvent-free conditions
• 2,5-dimethoxytetrahydrofuran

ACKNOWLEDGMENTS

S. N. M. thanks the Council of Scientific and Industrial Research and K. R. thanks the University Grants Commission, New Delhi, for the award of fellowships.

Notes

^a Reaction conditions: aniline (1.0 mmol), 2,5-dimethoxytetrahydrofuran (1.2 mmol), 100–120 °C, 4–7 h.

^b Isolated yield.