EcoFriendly Synthesis of Tetrahydropyrimidine Derivatives in Aqueous Medium Under Ultrasonic Irradiation

Abstract

A simple, efficient, and ecofriendly procedure was developed for the synthesis of 2-substituted 1,4,5,6-tetrahydropyrimidine derivatives catalyzed by N-bromosuccinimide using ultrasonic irradiation in aqueous medium. Prominent advantages of this new method are good yields, aqueous medium, short reaction times, and easy workup procedure. The compounds were characterized by infrared, NMR, liquid chromatography–mass spectrometry, and elemental analyses.

GRAPHICAL ABSTRACT

Keywords:

• Aqueous medium
• green synthesis
• NBS
• tetrahydropyrimidines
• ultrasound irradiation

ACKNOWLEDGMENT

The authors express their thanks to BRNS (DAE), BARC, Mumbai, India, for sanctioning a research project (2007/37/46/BRNS/2916).

Notes

Notes. Method A, ultrasonic irradiation; method B, conventional.

^a Isolated yields.

^b All the melting points were matched with the reported data.