Abstract
An efficient catalytic method for the synthesis of α, β-diamino acid derivatives has been developed via regioselective ring opening of aziridines by amines in the presence of indium(III) salt under very mild reaction conditions.
Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
We are grateful for the financial support from the National Science Foundation of China (20802072).
Notes
a Reaction conditions: compound 1 (0.4 mmol) and PMPNH2 (0.6 mmol) in DCM (1 mL), time (24 h).
b Isolated yields based on substrate 1.
c The ratio of 2a:3a refers to isolated yields.
a Reaction conditions: In(OTf)3 (10 mol %), compound 1 (0.4 mmol), PMPNH2 (0.6 mmol), solvent (1 mL), time (24 h).
b Isolated yields based on substrate 1.
c The ratio of 2a:3a refers to isolated yields.
a Reaction conditions: compound 1 (0.4 mmol), amine (0.6 mmol), In(OTf)3 (10 mol %), DCM (1 mL).
b Isolated yields based on substrate 1.
c The ratio of 2:3 refers to isolated yields.