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Abstract
We report here the synthesis of nitropyrazoles in good to excellent yields from iodopyrazoles over silica–sulfuric acid catalyst for the first time. The present procedure require less acid, offers a simplified workup procedure, and may be applied for the nitration of a wide variety of iodoazoles in drug and pharmaceutical industries.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
The Defence Research Development Organisation (DRDO), India, is gratefully acknowledged for financial support through the Advanced Centre of Research in High Energy Materials (ACRHEM).